Ppt New — Wilms Tumor

Follows a approach (immediate nephrectomy) for resectable unilateral tumors, followed by adjuvant chemotherapy based on surgical staging.

Residual tumor remains in the abdomen, either due to lymph node involvement, spillage during surgery, or incomplete resection.

The Children’s Oncology Group (COG) staging system is widely used:

| Risk Group | Criteria | Treatment | |------------|----------|------------| | | Stage I favorable histology, age <2y, tumor weight <550g | Nephrectomy only (no chemo) | | Standard | Most stage I-III favorable histology, no adverse molecular markers | Vincristine + actinomycin ± doxorubicin | | High | Diffuse anaplasia, stage IV favorable with blastemal type, TP53 mutation, 1q gain | Intensified chemo (regimen M) + radiation + consider experimental | wilms tumor ppt new

is becoming standard for risk assessment.

This article provides a structured, evidence-based outline for a state-of-the-art presentation.

Associated genes: WT1 (11p13), WT2 (11p15), CTNNB1 , and TP53 . The renal capsule is intact

Tumor is limited to the kidney and completely resected. The renal capsule is intact.

The SIOP approach performs followed by surgery and postoperative chemotherapy, with staging after preoperative treatment. This approach aims to reduce surgical complications and tumor rupture rates.

: Advances in multidisciplinary care have brought the overall 5-year survival rate to approximately 90–92%. 2. Pathogenesis & Etiology good prognosis) and Unfavorable Histology (anaplastic

Recent genomic sequencing highlights mutations in CTNNB1 , AMER1 (WTX), DROSHA , and DICER1 . Associated Syndromes

This public link is valid for 7 days and shares a thread, including any personal information you added. This link or copies made by others cannot be deleted. If you share with third parties, their policies apply. Can’t copy the link right now. Try again later.

Categorized into Favorable Histology (most common, good prognosis) and Unfavorable Histology (anaplastic, worse prognosis).